Splice to discover
Splice to understand

Deciphering the complexity of the transcriptome to illuminate cell physiology and disease pathology.

Our Products

Transcript knock-down

Antisense OligoNucleotides for target transcript knockdown

  • Induction of Nonsense-Mediated Decay (NMD)
  • Transcript-specific knockdown
  • Phenotype-based validation of targets
  • Pathway-centric and gene-family options
  • Overcomes off-target issues (e.g. siRNA)
Example Paper:
MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis
Koh et al. 2015. Nature

Transcript switching

Antisense OligoNucleotides for switching target transcript to an alternate splice-isoform
  • Modulation of specific splice event
  • Transcript-specific switching
  • Phenotype-based validation of targets
  • Pathway-centric and gene-family options
  • Covers major types of splicing patterns
Example Paper:
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
Georgilis et al. 2018. Cancer Cell

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Antisense OligoNucleotides

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NOA-Switch™

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NOA-NMD™

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Transcriptome coverage